Article
Serum levels of osteoprotegerin and osteoprotegerin polymorphisms in Gaucher disease.
British journal of haematology - 1 Apr 2006
Magal Itai, Lebel Ehud, Altarescu Gheona, Itzchaki Menachem, Rudensky Bernard, Foldes A Joseph, Zimran Ari, Elstein Deborah
Abstract excerpt
Bone involvement in Gaucher disease causes disability and reduced quality of life; loss of function and pain are important indications for enzyme replacement therapy. The purpose of this study was to ascertain whether osteoprotegerin (OPG), which decreases osteoclast activity, is indicative of incipient bone involvement by comparing OPG serum levels to Gaucher disease severity (SSI) and bone mineral density...
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