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Article

Sexual reproduction selects for robustness and negative epistasis in artificial gene networks.

Nature - 2 Mar 2006

Azevedo Ricardo B R, Lohaus Rolf, Srinivasan Suraj, Dang Kristen K, Burch Christina L

Abstract excerpt

The mutational deterministic hypothesis for the origin and maintenance of sexual reproduction posits that sex enhances the ability of natural selection to purge deleterious mutations after recombination brings them together into single genomes. This explanation requires negative epistasis, a type of genetic interaction where mutations are more harmful in combination than expected from their separate effects. The...

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PMID: 16511495
DOI: 10.1038/nature04488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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