Haploinsufficiency of the <i>Hmga1</i> Gene Causes Cardiac Hypertrophy and Myelo-Lymphoproliferative Disorders in Mice

Abstract excerpt

The HMGA1 protein is a major factor in chromatin architecture and gene control. It plays a critical role in neoplastic transformation. In fact, blockage of HMGA1 synthesis prevents rat thyroid cell transformation by murine transforming retroviruses, and an adenovirus carrying the HMGA1 gene in the antisense orientation induces apoptotic cell death in anaplastic human thyroid carcinoma cell lines, but not in...