Article
[Collagen type IV nephropathy: from thin basement membrane nephropathy to Alport syndrome].
Orvosi hetilap - 25 Dec 2005
Endreffy Emoke, Ondrik Zoltán, Kemény Eva, Vas Zoltán, Maróti Zoltán, Lencse Gerda, Bereczki Csaba, Haszon Ibolya, Túri Sándor, Iványi Béla
Abstract excerpt
INTRODUCTION: Collagen type IV nephropathy includes the Goodpasture syndrome, thin basement membrane nephropathy and the Alport syndrome. Mutations in the coding Col(IV)A3/A4 and Col(IV)A5 genes are probable causes of the latter two. Thin basement membrane nephropathy is mostly familial and has an autosomal dominant inheritance, at least 40% of the families have hematuria that co-segregates with the Col(IV)A3...
Topics
- Adolescent
- Adult
- Anti-Glomerular Basement Membrane Disease
- Collagen Type IV
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Glomerular Basement Membrane
- Hearing Loss
- Hematuria
- Heterozygote
- Humans
- Kidney
- Male