Article
Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy.
Cancer - 1 Mar 2006
Massacesi Cristian, Terrazzino Salvatore, Marcucci Fabiana, Rocchi Marco B, Lippe Paolo, Bisonni Renato, Lombardo Marco, Pilone Alberta, Mattioli Rodolfo, Leon Alberta
Abstract excerpt
BACKGROUND: In the current Phase II study, the authors evaluated the association between genomic polymorphic variants in uridine diphosphate glucuronosyl transferase (UGT1A1), methylenetetrahydrofolate reductase (MTHFR), and thymidylate synthase (TS) genes, and the incidence of the adverse effects of irinotecan and raltitrexed in previously heavily treated patients with metastatic colorectal carcinoma. METHODS:...
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