Article
Urokinase system expression in gastric carcinoma: prognostic impact in an independent patient series and first evidence of predictive value in preoperative biopsy and intestinal metaplasia specimens.
Cancer - 1 Mar 2006
Beyer Bianca C M, Heiss Markus Maria, Simon Erich H, Gruetzner Klaus-Uwe, Babic Rudolf, Jauch Karl-Walter, Schildberg Friedrich-Wilhelm, Allgayer Heike
Abstract excerpt
BACKGROUND: The prognostic relevance of urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PAR), and plasminogen activator inhibitor 1 (PAI-1) in gastric carcinoma was demonstrated in an independent patient series. To the authors' knowledge,the roles of these activators as predictors of aggressive phenotypes in preoperative biopsies, Helicobacter pylori infection, and intestinal metaplasia have to date...
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