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Article

Expression of mutant alpha (I)-procollagen in osteoblast and fibroblast cultures from a proband with osteogenesis imperfecta type IV.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 1992

Chipman S D, Shapiro J R, McKinstry M B, Stover M L, Branson P, Rowe D W

Abstract excerpt

This study compares the synthesis of mutant type I collagen in cultured dermal fibroblasts and trabecular osteoblasts that were isolated from a patient with moderately severe osteogenesis imperfecta (type IV). Previous study of this patient's dermal fibroblasts revealed a 2000 dalton deletion located in cyanogen bromide peptide 4 of alpha 2(I)-collagen. The phenotype of the bone cell cultures was defined by a 3-4...

Topics

Alkaline Phosphatase
Amino Acid Sequence
Base Sequence
Cells, Cultured
Collagen
DNA
Electrophoresis, Polyacrylamide Gel
Exons
Female
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Middle Aged

Molecular Sequence Data

Mutation

Osteoblasts

Osteogenesis Imperfecta

Polymerase Chain Reaction

Procollagen

Source

Identifiers

PMID: 1642148
DOI: 10.1002/jbmr.5650070709

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1642148-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Expression of mutant alpha (I)-procollagen in osteoblast and fibroblast cultures from a proband with osteogenesis imperfecta type IV.PMID 1642148Read ↗

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