Influence of CYP3A5 gene polymorphisms of donor rather than recipient to tacrolimus individual dose requirement in liver transplantation.

doi:10.1097/01.tp.0000188118.34633.bf

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Article

Influence of CYP3A5 gene polymorphisms of donor rather than recipient to tacrolimus individual dose requirement in liver transplantation.

Transplantation - 15 Jan 2006

Yu Songfeng, Wu Lihua, Jin Jing, Yan Sheng, Jiang Guoping, Xie Haiyang, Zheng Shusen

This publication is marked as retracted by the source.

Abstract excerpt

BACKGROUND: Tacrolimus is a widely used immunosuppressant in organ transplantation, but it is characterized by a narrow therapeutic index and high interindividual variations of its pharmacokinetics. Tacrolimus is a substrate for CYP3A. It has been conjectured that CYP3A5 polymorphism is associated with tacrolimus pharmacokinetic variations. The objective of this study was to evaluate the contribution of...

Read the complete abstract on PubMed

Topics

Adult
Aged
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
Dose-Response Relationship, Drug
Genotype
Humans
Liver Transplantation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Polymorphism, Genetic

Retrospective Studies

Tacrolimus

Tissue Donors

Source

Open in PubMed

Identifiers

PMID: 16421475
DOI: 10.1097/01.tp.0000188118.34633.bf

Genes

CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.