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Article

Antimyoclonic effect of levetiracetam in MERRF syndrome.

Journal of the neurological sciences - 15 Apr 2006

Mancuso Michelangelo, Galli Renato, Pizzanelli Chiara, Filosto Massimiliano, Siciliano Gabriele, Murri Luigi

Abstract excerpt

The treatment of progressive myoclonic epilepsy (PME) is largely empirical, even though valproic acid (VPA) is usually considered the drug of first choice. However, VPA should be used with caution in PME due to mitochondrial dysfunction, i.e. in MERRF (myoclonic epilepsy with ragged red fibers) syndrome, because of its interaction with mitochondrial respiration and metabolism. Levetiracetam (LEV) treatment was...

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Identifiers

PMID: 16414077
DOI: 10.1016/j.jns.2005.11.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antimyoclonic effect of levetiracetam in MERRF syndrome.PMID 16414077Read ↗

When should MERRF (myoclonus epilepsy associated with ragged-red fibers) be the diagnosis?Semantic proximity Read ↗

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"Myo-neuropathy" is commonly associated with mitochondrial tRNALysine mutation.Semantic proximity Read ↗

Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA(Lys) mutation.Semantic proximity Read ↗

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Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome: report of a Chinese family with mitochondrial DNA point mutation in tRNA(Lys) gene.Semantic proximity Read ↗

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