Article
Late-onset and typical Huntington disease families from Crete have distinct genetic origins.
International journal of molecular medicine - 1 Feb 2006
Kartsaki Eleonora, Spanaki Cleanthe, Tzagournissakis Minas, Petsakou Aphrodite, Moschonas Nicholas, Macdonald Marcy, Plaitakis Andreas
Abstract excerpt
HD families in which late-onset occurs consistently in affected members are rare. The objectives of this work was to study such late-onset HD families encountered on Crete, and to trace their genetic origin. Nine late-onset HD kindreds (61 affected members) were studied along with two typical HD families (17 affected members). We genotyped 33 late-onset Cretan HD chromosomes, 9 Cretan typical HD chromosomes and...
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