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Article

Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia.

American journal of human genetics - 1 Jan 2006

Schumacher Johannes, Anthoni Heidi, Dahdouh Faten, König Inke R, Hillmer Axel M, Kluck Nadine, Manthey Malou, Plume Ellen, Warnke Andreas, Remschmidt Helmut, Hülsmann Jutta, Cichon Sven, Lindgren Cecilia M, Propping Peter, Zucchelli Marco, Ziegler Andreas, Peyrard-Janvid Myriam, Schulte-Körne Gerd, Nöthen Markus M, Kere Juha

Abstract excerpt

We searched for linkage disequilibrium (LD) in 137 triads with dyslexia, using markers that span the most-replicated dyslexia susceptibility region on 6p21-p22, and found association between the disease and markers within the VMP/DCDC2/KAAG1 locus. Detailed refinement of the LD region, involving...

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Identifiers

PMID: 16385449
DOI: 10.1086/498992
PMCID: PMC1380223

Genes

DCDC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16385449-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia.PMID 16385449Read ↗

The role of gene DCDC2 in German dyslexics.Semantic proximity Read ↗

Meta-analysis of the association between DCDC2 polymorphisms and risk of dyslexia.Semantic proximity Read ↗

Association study of developmental dyslexia candidate genes DCDC2 and KIAA0319 in Chinese population.Semantic proximity Read ↗

A theoretical molecular network for dyslexia: integrating available genetic findings.Semantic proximity Read ↗

Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.Semantic proximity Read ↗

Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort.Semantic proximity Read ↗

Analysis of genetic variants of dyslexia candidate genes KIAA0319 and DCDC2 in Indian population.Semantic proximity Read ↗

DCDC2 is associated with reading disability and modulates neuronal development in the brain.Semantic proximity Read ↗

Genetic variant in DIP2A gene is associated with developmental dyslexia in Chinese population.Semantic proximity Read ↗

Polymorphisms in DCDC2 and S100B associate with developmental dyslexia.Semantic proximity Read ↗

Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21.Semantic proximity Read ↗

Mutation of the dyslexia-associated gene Dcdc2 impairs LTM and visuo-spatial performance in mice.Semantic proximity Read ↗

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