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Article

Clinical heterogeneity of α‐synuclein gene duplication in Parkinson's disease

15 Dec 2005

Abstract excerpt

OBJECTIVE: Recently, genomic multiplications of alpha-synuclein gene (SNCA) have been reported to cause hereditary early-onset parkinsonism. The objective of this study was to assess the frequency of SNCA multiplications among autosomal dominant hereditary Parkinson's disease (ADPD). METHODS: We screened 113 ADPD probands and 200 sporadic PD cases by quantitative polymerase chain reaction and confirmed SNCA...

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PMID: 16358335
DOI: 10.1002/ana.20753

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