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Prognostic and Functional Significance of Thromboxane Synthase Gene Overexpression in Invasive Bladder Cancer

15 Dec 2005

Abstract excerpt

Thromboxane synthase (TXAS) is one of the enzymes downstream from cyclooxygenase-2 and catalyzes the synthesis of thromboxane A(2) (TXA(2)). TXAS was among the genes we identified based on its overexpression in invasive bladder tumors. TXAS is overexpressed in common forms of bladder tumors: 69 of 97 (71.1%) transitional cell carcinoma (TCC), 38 of 53 (71.6%) squamous cell carcinoma, and 5 of 11 (45.5%)...

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PMID: 16357168
DOI: 10.1158/0008-5472.can-05-1622

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