Article
Identification and characterization of the genes involved in glycosylation pathways of mycobacterial glycopeptidolipid biosynthesis.
Journal of bacteriology - 1 Jan 2006
Miyamoto Yuji, Mukai Tetsu, Nakata Noboru, Maeda Yumi, Kai Masanori, Naka Takashi, Yano Ikuya, Makino Masahiko
Abstract excerpt
Glycopeptidolipids (GPLs) are major components present on the outer layers of the cell walls of several nontuberculous mycobacteria. GPLs are antigenic molecules and have variant oligosaccharides in mycobacteria such as Mycobacterium avium. In this study, we identified four genes (gtf1, gtf2, gtf3, and gtf4) in the genome of Mycobacterium smegmatis. These genes were independently inactivated by homologous...
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