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Article

New approaches to the analysis of palindromic sequences from the human genome: evolution and polymorphism of an intronic site at the NF1 locus.

Nucleic acids research - 9 Dec 2005

Lewis Susanna M, Chen Shuang, Strathern Jeffrey N, Rattray Alison J

Abstract excerpt

The nature of any long palindrome that might exist in the human genome is obscured by the instability of such sequences once cloned in Escherichia coli. We describe and validate a practical alternative to the analysis of naturally-occurring palindromes based upon cloning and propagation in Saccharomyces cerevisiae. With this approach we have investigated an intronic sequence in the human Neurofibromatosis 1 (NF1)...

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Identifiers

PMID: 16340004
DOI: 10.1093/nar/gni189
PMCID: PMC1310899

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New approaches to the analysis of palindromic sequences from the human genome: evolution and polymorphism of an intronic site at the NF1 locus.PMID 16340004Read ↗

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