Article
Simple PCR heteroduplex, SSCP mutation screening methods for the detection of novel catalase mutations in Hungarian patients with type 2 diabetes mellitus.
Clinical chemistry and laboratory medicine - 1 Jan 2005
Vitai Márta, Fátrai Szabolcs, Rass Péter, Csordás Melinda, Tarnai Ildikó
Abstract excerpt
BACKGROUND: The enzyme catalase is the main regulator of hydrogen peroxide metabolism. Deficiency of catalase may cause high concentrations of hydrogen peroxide and increase the risk of the development of pathologies for which oxidative stress is a contributing factor, for example, type 2 diabetes mellitus. Catalase deficiency has been reported to be associated with increased frequency of diabetes mellitus in a...
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