Article
Distribution of type IV collagen in the cochlea in Alport syndrome.
Archives of otolaryngology--head & neck surgery - 1 Nov 2005
Zehnder Andreas F, Adams Joe C, Santi Peter A, Kristiansen Arthur G, Wacharasindhu Chitsuda, Mann Sabine, Kalluri Raghu, Gregory Martin C, Kashtan Clifford E, Merchant Saumil N
Abstract excerpt
OBJECTIVE: To determine the distribution of alpha1, alpha3, and alpha5 chains of type IV collagen in the cochlea in Alport syndrome. DESIGN: Case-control study. PATIENTS: Two patients with sensorineural hearing loss due to Alport syndrome. Both patients had known mutations in the COL4A5 gene. MAIN OUTCOME MEASURES: Immunostaining was used to study the distribution of type IV collagen (alpha1, alpha3, and alpha5...
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