Article
Glutathione S-transferase M1 gene polymorphism in Thai nasopharyngeal carcinoma.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2000
Tiwawech Danai, Srivatanakul Petcharin, Karalak Anant, Ishida Takafumi
Abstract excerpt
Nasopharyngeal carcinoma (NPC) is a serious health problem in Thailand. It is caused by the combined effects of Epstein-Barr virus (EBV), carcinogens and genetic susceptibility. The glutathione S-transferase M1 gene (GSTM1) encodes a phase II enzyme responsible for detoxifying carcinogenic electrophiles. Polymorphic null forms of the gene GSTM1 lack enzyme activity and have been associated with susceptibility to...
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