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Article

Correction of murine hemophilia A by hematopoietic stem cell gene therapy.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Dec 2005

Moayeri Morvarid, Hawley Teresa S, Hawley Robert G

Abstract excerpt

A serious complication of current protein replacement therapy for hemophilia A patients with coagulation factor VIII (FVIII) deficiency is the frequent development of anti-FVIII inhibitor antibodies that preclude therapeutic benefit from further treatment. Induction of tolerance by persistent high-level FVIII synthesis following transplantation with hematopoietic stem cells expressing a retrovirally delivered...

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Identifiers

PMID: 16226058
DOI: 10.1016/j.ymthe.2005.09.007
PMCID: PMC2387180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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