Article
Interleukin-13 and interleukin-4 induce vascular endothelial growth factor release from airway smooth muscle cells: role of vascular endothelial growth factor genotype.
American journal of respiratory cell and molecular biology - 1 Feb 2006
Faffe Débora S, Flynt Lesley, Bourgeois Kerri, Panettieri Reynold A, Shore Stephanie A
Abstract excerpt
Th2 cytokines induce the release of vascular endothelial growth factor (VEGF) from cultured human airway smooth muscle cells. The objective of this study was to examine the mechanistic basis for IL-4- and IL-13-induced VEGF release and to determine whether genetic differences are responsible for donor-to-donor variability in VEGF release. We measured VEGF mRNA expression by real-time PCR, mRNA stability using...
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