Article
Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Oct 2005
Roman-Gomez Jose, Jimenez-Velasco Antonio, Agirre Xabier, Prosper Felipe, Heiniger Anabel, Torres Antonio
Abstract excerpt
PURPOSE: To examine cancer genes undergoing epigenetic inactivation in a set of T-cell acute lymphoblastic leukemias (T-ALLs) to obtain the CpG island methylator phenotype (CIMP) in the disease and its possible correlation with clinical features and outcome of the patients. PATIENTS AND METHODS: Methylation-specific polymerase chain reaction was used to analyze methylation of the ADAMTS-1, ADAMTS-5, APAF-1,...
Read the complete abstract on PubMedTopics
- Adolescent
- Adult
- Biomarkers, Tumor
- Child
- Child, Preschool
- CpG Islands