Article
Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers.
Human mutation - 1 Oct 2005
Cohn Jonathan A, Neoptolemos John P, Feng Jinong, Yan Jin, Jiang Zefei, Greenhalf William, McFaul Christopher, Mountford Roger, Sommer Steve S
Abstract excerpt
Cystic fibrosis (CF) is a recessive disease caused by mutations of the CF transmembrane conductance regulator (CFTR) gene. The risk of idiopathic chronic pancreatitis (ICP) is increased in individuals who have CFTR genotypes containing a CF-causing mutation plus a second pathogenic allele. It is unknown whether the risk of ICP is increased in CF carriers who have one CF-causing mutation plus one normal allele. In...
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