Article
Sequencing arrays for screening multiple genes associated with early-onset human retinal degenerations on a high-throughput platform.
Investigative ophthalmology & visual science - 1 Sept 2005
Mandal Md Nawajes A, Heckenlively John R, Burch Tracy, Chen Lianchun, Vasireddy Vidyullatha, Koenekoop Robert K, Sieving Paul A, Ayyagari Radha
Abstract excerpt
PURPOSE: To develop and apply microarray-based resequencing technology to detect sequence alterations in multiple autosomal recessive retinal disease genes on a single high-throughput platform. METHODS: Oligonucleotides corresponding to both strands of the target exons and the flanking intron sequences of 29,214 bp from 11 genes associated with autosomal recessive retinitis pigmentosa (arRP) were tiled on 20 x...
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