Article
The first 30 minutes in the life of a virus: unREST in the nucleus.
Cell cycle (Georgetown, Tex.) - 1 Aug 2005
Roizman Bernard, Gu Haidong, Mandel Gail
Abstract excerpt
On entry of viral DNA into cells, a competition ensues between cellular factors that silence viral genes and transcriptional factors that block silencing and transcribe the DNA. In the case of herpes simplex virus 1, the first set of genes expressed after infection-are induced by a viral protein (alphaTIF or VP16). Expression of later (beta,gamma) genes in cells infected at low ratios of virus per cells requires...
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