Gene expression perturbation in vitro--a growing case for three-dimensional (3D) culture systems.

Abstract excerpt

Cells grown in vitro are dramatically perturbed by their new microenvironment. Analyses of genome-wide gene expression levels offer a first glance at which genes and pathways are affected in cell lines as compared to their tissues of origins. We have summarized available gene expression data and review how cell lines adapt to in vitro environments, to what degree they express markers of their tissues of origins...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Adhesion
• Share to Cell Proliferation
• Share to Coculture Techniques