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Article

Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses.

PLoS biology - 1 Sept 2005

Holmes Edward C, Ghedin Elodie, Miller Naomi, Taylor Jill, Bao Yiming, St George Kirsten, Grenfell Bryan T, Salzberg Steven L, Fraser Claire M, Lipman David J, Taubenberger Jeffery K

Abstract excerpt

Understanding the evolution of influenza A viruses in humans is important for surveillance and vaccine strain selection. We performed a phylogenetic analysis of 156 complete genomes of human H3N2 influenza A viruses collected between 1999 and 2004 from New York State, United States, and observed multiple co-circulating clades with different population frequencies. Strikingly, phylogenies inferred for individual...

Topics

Evolution, Molecular
Genes, Viral
Genetic Variation
Genome
Humans
Influenza A Virus, H3N2 Subtype
Phylogeny
Reassortant Viruses
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16026181
DOI: 10.1371/journal.pbio.0030300
PMCID: PMC1180517

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