Article
CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitors.
Circulation research - 19 Aug 2005
Romagnani Paola, Annunziato Francesco, Liotta Francesco, Lazzeri Elena, Mazzinghi Benedetta, Frosali Francesca, Cosmi Lorenzo, Maggi Laura, Lasagni Laura, Scheffold Alexander, Kruger Manuela, Dimmeler Stefanie, Marra Fabio, Gensini Gianfranco, Maggi Enrico, Romagnani Sergio
Abstract excerpt
Endothelial progenitor cells (EPCs) seem to be a promising tool for cell therapy of acute myocardial infarction, but their nature is still unclear. We show here that EPCs obtainable from peripheral blood (PB) derive from the adhesion-related selection in culture of a subset of CD14+ cells, which, when assessed by the highly-sensitive antibody-conjugated magnetofluorescent liposomes (ACMFL) technique, were found...
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