Responsiveness to Cetuximab without Mutations in<i>EGFR</i>

Abstract excerpt

T790M mutation was shown to confer resistance to gefitinib after it was introduced into the sequence of the wild-type EGFR and L858R mutant EGFR in vitro. 2,3 The T790M mutation results in steric hindrance of binding of gefitinib to the ATPkinase-binding pocket.The T790M mutation may cause acquired resistance to gefitinib. 2,3Our patient had concomitant T790M and L858R EGFR mutations in the original lung-biopsy...

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