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Article

No evidence for epigenetic inactivation of fumarate hydratase in leiomyomas and leiomyosarcomas.

Cancer letters - 8 Apr 2006

Barker Karen T, Spendlove Hayley E, Banu Nassera S, Bridge Julia A, Fisher Cyril, Shipley Janet, Garrett Michelle, Manyonda Isaac, Houlston Richard S

Abstract excerpt

Germline mutations in Fumarate Hydratase (FH) cause the development of leiomyomas and leiomyosarcomas in the syndromes Multiple Cutaneous and Uterine Leiomyomata (MCUL1) and Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC). There is little evidence, however, that FH mutation plays a role in the development of sporadic leiomyomas or leiomyosarcomas. Such observations do not, however, exclude a role for FH...

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Share to Epigenesis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15949892
DOI: 10.1016/j.canlet.2005.04.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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No evidence for epigenetic inactivation of fumarate hydratase in leiomyomas and leiomyosarcomas.PMID 15949892Read ↗

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Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors.Semantic proximity Read ↗

Morphologic and Molecular Characteristics of Uterine Leiomyomas in Hereditary Leiomyomatosis and Renal Cancer (HLRCC) SyndromeSemantic proximity Read ↗

Fumarase-deficient Uterine LeiomyomasSemantic proximity Read ↗

Segregation, immunohistochemical, molecular and functional analyses classify a novel missense variant in fumarate hydratase (FH) as pathogenic.Semantic proximity Read ↗

Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomasSemantic proximity Read ↗

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Absence of fumarate hydratase mutation in a family with cutaneous leiomyosarcoma and renal cancer.Semantic proximity Read ↗

Association of Germline Mutations in the Fumarate Hydratase Gene and Uterine Fibroids in Women With Hereditary Leiomyomatosis and Renal Cell CancerSemantic proximity Read ↗

Targeted sequencing of FH-deficient uterine leiomyomas reveals biallelic inactivating somatic fumarase variants and allows characterization of missense variantsSemantic proximity Read ↗

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