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Article

The biochemical phenotypes of two inborn errors in the biosynthesis of aldosterone.

The Journal of clinical endocrinology and metabolism - 1 Jun 1992

Ulick S, Wang J Z, Morton D H

Abstract excerpt

Two inborn errors in the methyl oxidation of corticosterone to form aldosterone correspond to the two oxygenation-hydroxylation reactions required for this transformation. Both defects are characterized by overproduction of corticosterone of glomerulosa zone origin and deficient synthesis of aldosterone. In the type 1 corticosterone methyl oxidase defect (CMO I) impairment in the first step is reflected in...

Topics

18-Hydroxycorticosterone
Adolescent
Adrenal Cortex Hormones
Adult
Aldosterone
Child
Child, Preschool
Corticosterone
Cytochrome P-450 CYP11B2
Female
Humans
Hydrocortisone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Metabolism, Inborn Errors

Mixed Function Oxygenases

Phenotype

Source

Identifiers

PMID: 1592889
DOI: 10.1210/jcem.74.6.1592889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1592889-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The biochemical phenotypes of two inborn errors in the biosynthesis of aldosterone.Semantic proximity Read ↗

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