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Article

Characterization of four variant forms of human propionyl-CoA carboxylase expressed in Escherichia coli.

The Journal of biological chemistry - 29 Jul 2005

Jiang Hua, Rao K Sudhindra, Yee Vivien C, Kraus Jan P

Abstract excerpt

Propionyl-CoA carboxylase (PCC) is a biotin-dependent mitochondrial enzyme that catalyzes the conversion of propionyl-CoA to D-methylmalonyl-CoA. PCC consists of two heterologous subunits, alpha PCC and beta PCC, which are encoded by the nuclear PCCA and PCCB genes, respectively. Deficiency of PCC results in a metabolic disorder, propionic acidemia, which is sufficiently severe to cause neonatal death. We have...

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Source

Identifiers

PMID: 15890657
DOI: 10.1074/jbc.M413281200

Genes

PCCB
PCCA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of four variant forms of human propionyl-CoA carboxylase expressed in Escherichia coli.PMID 15890657Read ↗

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Functional characterization of PCCA mutations causing propionic acidemia.Semantic proximity Read ↗

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Genetic heterogeneity in propionic acidemia patients with alpha-subunit defects. Identification of five novel mutations, one of them causing instability of the protein.Semantic proximity Read ↗

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