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Article

Voice abnormality in adults with congenital and adult-acquired growth hormone deficiency.

The Journal of clinical endocrinology and metabolism - 1 Jul 2005

Moore Christopher, Shalet Stephen, Manickam Kathiresan, Willard Terry, Maheshwari Hiralal, Baumann Gerhard

Abstract excerpt

CONTEXT: Adult males with congenital, untreated, severe GH deficiency (GHD) due to genetic GHRH receptor deficiency exhibit distinctive, high-pitched, and raspy voice characteristics. OBJECTIVE/DESIGN: To determine the physical underpinning of this phenomenon, we performed voice recordings, translarynx impedance measurements, spectral analysis, and estimates of spectral complexity [approximate entropy (ApEn)] in...

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Identifiers

PMID: 15870127
DOI: 10.1210/jc.2004-2558

Genes

GHRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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