Article
Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice.
Nature medicine - 1 Jun 2005
Davies Janet E, Wang Lin, Garcia-Oroz Lourdes, Cook Lynnette J, Vacher Coralie, O'Donovan Dominic G, Rubinsztein David C
Abstract excerpt
The muscular dystrophies are a heterogeneous group of disorders for which there are currently no cures. Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant late-onset, progressive disease that generally presents in the fifth or sixth decade with dysphagia, ptosis and proximal limb weakness. OPMD is caused by the abnormal expansion of a (GCG)n trinucleotide repeat in the coding region of the...
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