Isolation and characterization of a highly divergent HIV-2[GH-2]: generation of an infectious molecular clone and functional analysis of its rev-responsive element in response to primate retrovirus transactivators (Rev and Rex).

doi:10.1016/0042-6822(92)90540-6

Article

Isolation and characterization of a highly divergent HIV-2[GH-2]: generation of an infectious molecular clone and functional analysis of its rev-responsive element in response to primate retrovirus transactivators (Rev and Rex).

Virology - 1 Jun 1992

Kawamura M, Katahira J, Fukasawa M, Sakuragi J, Ishikawa K, Nakai M, Mingle J A, Osei-Kwasi M, Netty V B, Akari H

Abstract excerpt

A highly divergent HIV-2 designated as HIV-2[GH-2] was obtained from an AIDS-related complex (ARC) patient in Ghana. A full-length molecular clone of this isolate was obtained and a biologically active clone was constructed. Its restriction pattern differed from that of prototype HIV-2[GH-1] in 25 of 35 restriction sites, but was strikingly similar to a previously characterized HIV-2 isolate from a Ghanaian...

Topics

Cloning, Molecular
DNA, Viral
Gene Expression Regulation, Viral
Genes, pX
Genes, rev
Genetic Variation
HIV Long Terminal Repeat
HIV-2
Restriction Mapping
Sequence Homology, Nucleic Acid

Isolation and characterization of a highly divergent HIV-2[GH-2]: generation of an infectious molecular clone and functional analysis of its rev-responsive element in response to primate retrovirus transactivators (Rev and Rex).

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