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Article

Transforming growth factor-beta induces endothelin-1 expression through activation of the Smad signaling pathway.

Journal of cardiovascular pharmacology - 1 Nov 2004

Rodríguez-Pascual Fernando, Reimunde Francisco Manuel, Redondo-Horcajo Mariano, Lamas Santiago

Abstract excerpt

Expression of the endothelin-1 gene is subject to complex regulation by different factors, among which transforming growth factor-beta is one of the most important. We have analyzed the mechanism by which transforming growth factor-beta increases endothelin-1 expression in vascular endothelial cells. Transcriptional activation of the endothelin-1 promoter accounted for the transforming growth factor-beta-induced...

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Identifiers

PMID: 15838328
DOI: 10.1097/01.fjc.0000166216.27544.22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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