Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens.

doi:10.1186/1471-2407-5-38

Back to search

Article

Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens.

BMC cancer - 12 Apr 2005

Kalina Tomas, Vaskova Martina, Mejstrikova Ester, Madzo Jozef, Trka Jan, Stary Jan, Hrusak Ondrej

Abstract excerpt

BACKGROUND: Aberrant expression of myeloid antigens (MyAgs) on acute lymphoblastic leukemia (ALL) cells is a well-documented phenomenon, although its regulating mechanisms are unclear. MyAgs in ALL are interpreted e.g. as hallmarks of early differentiation stage and/or lineage indecisiveness. Granulocytic marker CD66c -- Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is aberrantly expressed...

Topics

Adolescent
Antigens, CD
Antigens, Differentiation, Myelomonocytic
Blotting, Western
CD13 Antigens
Cell Adhesion Molecules
Cell Membrane
Child
Child, Preschool
Cohort Studies

Cytoplasm

Czech Republic

Disease-Free Survival

Flow Cytometry

GPI-Linked Proteins

Gene Expression Regulation, Neoplastic

Genotype

Glycosylation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.