Article
Serum alters the uptake and biologic activity of CpG oligodeoxynucleotides in B cell chronic lymphocytic leukemia.
Oligonucleotides - 1 Jan 2005
Jahrsdörfer Bernd, Blackwell Sue E, Wooldridge James E, Taylor Christiana M, Weiner George J
Abstract excerpt
Immunostimulatory CpG-containing oligodeoxynucleotides (CpG ODN) have a number of effects on B cells, including upregulation of immunogenic molecules, and, therefore, appear attractive as potential components of immunotherapy for B cell chronic lymphocytic leukemia (B-CLL). Previous in vitro studies investigating the effect of CpG ODN on B-CLL cells used serum-low conditions and did not account for the...
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