Regulation of meiotic maturation in the mammalian oocyte: Inteplay between exogenous cues and the microtubule cytoskeleton

Abstract excerpt

Mammalian oocytes exhibit a series of cell cycle transitions that coordinate the penultimate events of meiosis with the onset of embryogenesis at fertilization. The execution of these cell cycle transitions, at G2/M of meiosis-I and metaphase/anaphase of meiosis I and II, involve both biosynthetic and post-translational modifications that directly modulate centrosome and microtubule behavior. Specifically,...

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