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Article

Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone.

Cell - 25 Feb 2005

Chien Kenneth R, Karsenty Gerard

Abstract excerpt

Human aging is characterized by debilitating diseases, including heart failure, cardiac pacemaker defects, muscle wasting, and osteoporosis, in heart, skeletal muscle, and bone. Recent studies are identifying pathways for these aging-related diseases by examining how the process of aging influences tissue-specific progenitors and differentiated cell lineages in these organ systems. These advances form a...

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PMID: 15734685
DOI: 10.1016/j.cell.2005.02.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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