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Effect of Human Cytomegalovirus on Expression of MHC Class I-Related Chains A

1 Mar 2005

Abstract excerpt

The MHC-encoded MHC class I-related chains A (MICA) glycoproteins are known to enhance the functions of NK and T cells by ligating the stimulating receptor NKG2D and appear to play an important role in host defense. Human CMV (HCMV) evades the immune response in many different ways, but has not previously been found to down-regulate MICA. We have found that a common form of MICA, which has a nucleotide insertion...

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PMID: 15728525
DOI: 10.4049/jimmunol.174.5.3098

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