Article
Association analysis of the monoamine oxidase A and B genes with attention deficit hyperactivity disorder (ADHD) in an Irish sample: preferential transmission of the MAO-A 941G allele to affected children.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2005
Domschke Katharina, Sheehan Karen, Lowe Naomi, Kirley Aiveen, Mullins Celine, O'sullivan Roderick, Freitag Christine, Becker Tim, Conroy Judith, Fitzgerald Michael, Gill Michael, Hawi Ziarih
Abstract excerpt
Pharmacological and genetic studies suggest the importance of the dopaminergic, serotonergic, and noradrenergic systems in the pathogenesis of attention deficit hyperactivity disorder (ADHD). Monoamine oxidases A and B (MAO-A and MAO-B) degrade biogenic amines such as dopamine and serotonin and thereby control the levels of these neurotransmitters in the central nervous system. We examined four polymorphisms in...
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