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Article

Effect of Leflunomide and Cidofovir on Replication of BK Virus in an In Vitro Culture System

31 Dec 2004

Abstract excerpt

BACKGROUND: Cidofovir and Leflunomide are used empirically in the treatment of BK virus nephropathy. The aim of this study is to quantify the antiviral activity of these drugs. METHODS: BK virus was grown in a cell-culture system. The rate of viral replication in the presence or absence of the drug being tested was assessed using a quantitative polymerase chain reaction assay. RESULTS: The inhibitory...

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PMID: 15714178
DOI: 10.1097/01.tp.0000149338.97084.5f

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