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What are the effects of maternal and pre-adult environments on ageing in humans, and are there lessons from animal models?

Mechanisms of ageing and development - 1 Mar 2005

Brakefield Paul M, Gems David, Cowen Tim, Christensen Kaare, Grubeck-Loebenstein Beatrix, Keller Laurent, Oeppen Jim, Rodriguez-Pena Angeles, Stazi Maria Antonietta, Tatar Marc, Westendorp Rudi G J

Abstract excerpt

An open issue in research on ageing is the extent to which responses to the environment during development can influence variability in life span in animals, and the health profile of the elderly in human populations. Both affluence and adversity in human societies have profound impacts on survivorship curves, and some of this effect may be traceable to effects in utero or in infancy. The Barker Hypothesis that...

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PMID: 15664631
DOI: 10.1016/j.mad.2004.07.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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