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Productive Replication of Human Adenovirus Type 5 in Canine Cells

21 Dec 2004

Abstract excerpt

Development of immunocompetent patient-like models that allow direct analysis of human adenovirus-based conditionally replicative adenoviruses (CRAds) would be beneficial for the advancement of these oncolytic agents. To this end, we explored the possibility of cross-species replication of human adenovirus type 5 (Ad5) in canine cells. With a panel of canine tumor cell lines of both epithelial and mesenchymal...

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PMID: 15613357
DOI: 10.1128/jvi.79.2.1308-1311.2005

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