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Article

Thermodynamic consequences of disrupting a water-mediated hydrogen bond network in a protein:pheromone complex.

Protein science : a publication of the Protein Society - 1 Jan 2005

Sharrow Scott D, Edmonds Katherine A, Goodman Michael A, Novotny Milos V, Stone Martin J

Abstract excerpt

The mouse pheromones (+/-)-2-sec-butyl-4,5-dihydrothiazole (SBT) and 6-hydroxy-6-methyl-3-heptanone (HMH) bind into an occluded hydrophobic cavity in the mouse major urinary protein (MUP-1). Although the ligands are structurally unrelated, in both cases binding is accompanied by formation of a similar buried, water-mediated hydrogen bond network between the ligand and several backbone and side chain groups on the...

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Identifiers

PMID: 15608125
DOI: 10.1110/ps.04912605
PMCID: PMC2253314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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