Article
Screening for mutations in the WNT-4 gene in patients with 46,XX true hermaphroditism.
Molecular genetics and metabolism - 1 Dec 2004
Canto Patricia, Razo Selene, Söderlund Daniela, Calzada-León Raúl, de la Luz Ruiz-Reyes María, Ramón Guillermo, Braun-Roth Gabriela, Méndez Juan Pablo
Abstract excerpt
We investigated if eight SRY-negative 46,XX true hermaphrodites presented mutations in WNT-4, in blood leukocytes and/or gonadal tissue, as the cause of their disorder. We designed the sequences of the reverse primer of exon 1 and the primers of exons 2-5. Direct sequencing of all five exons demonstrated no mutant alleles in any of the patients. The possibility of the existence of causative mutations in the...
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