Article
The -1997 G/T polymorphism in the COLIA1 upstream regulatory region is associated with hip bone mineral density (BMD) in Chinese nuclear families.
Calcified tissue international - 1 Feb 2005
Zhang Yuan-Yuan, Lei Shu-Feng, Mo Xiao-Yang, Wang Yan-Bo, Li Miao-Xin, Deng Hong-Wen
Abstract excerpt
Type I collagen is the most abundant protein of bone matrix, and the collagen type I alpha 1(COLIA1) gene has been considered one of the most important candidate genes for osteoporosis. In this study, we simultaneously tested linkage and/or association of the -1997 G/T polymorphism in the COLIA1 upstream regulatory region with the variation of bone mineral density (BMD) in 1263 subjects from 402 Chinese nuclear...
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