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Determinants of High Titer in Recombinant Porcine Endogenous Retroviruses

24 Nov 2004

Abstract excerpt

Porcine endogenous retroviruses (PERVs) pose a potential stumbling block for therapeutic xenotransplantation, with the greatest threat coming from viruses generated by recombination between members of the PERV subgroup A (PERV-A) and PERV-C families (PERV-A/C recombinants). PERV-A and PERV-B have been shown to infect human cells in culture, albeit with low titers. PERV-C has a more restricted host range and...

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PMID: 15564495
DOI: 10.1128/jvi.78.24.13871-13879.2004

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