Article
Heptad repeat 2-based peptides inhibit avian sarcoma and leukosis virus subgroup a infection and identify a fusion intermediate.
Journal of virology - 1 Dec 2004
Netter Robert C, Amberg Sean M, Balliet John W, Biscone Mark J, Vermeulen Arwen, Earp Laurie J, White Judith M, Bates Paul
Abstract excerpt
Fusion proteins of enveloped viruses categorized as class I are typified by two distinct heptad repeat domains within the transmembrane subunit. These repeats are important structural elements that assemble into the six-helix bundles characteristic of the fusion-activated envelope trimer. Peptides derived from these domains can be potent and specific inhibitors of membrane fusion and virus infection. To...
Topics
- Amino Acid Sequence
- Animals
- Avian Leukosis Virus
- Avian Sarcoma Viruses
- Cell Fusion
- Cell Line
- Membrane Fusion
- Molecular Sequence Data
- Mutation
- Peptides
- Repetitive Sequences, Amino Acid
- Viral Fusion Proteins