Alteration of the timing of implantation by in vivo gene transfer: delay of implantation by suppression of nuclear factor kappaB activity and partial rescue by leukemia inhibitory factor.

doi:10.1016/j.bbrc.2004.07.045

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Alteration of the timing of implantation by in vivo gene transfer: delay of implantation by suppression of nuclear factor kappaB activity and partial rescue by leukemia inhibitory factor.

Biochemical and biophysical research communications - 3 Sept 2004

Nakamura Hitomi, Kimura Tadashi, Ogita Kazuhide, Koyama Shinsuke, Tsujie Tomoko, Tsutsui Tateki, Shimoya Koichiro, Koyama Masayasu, Kaneda Yasufumi, Murata Yuji

Abstract excerpt

Nuclear factor kappaB (NF-kappaB) is activated in the murine endometrium during implantation period [Am. J. Reprod. Immunol. 51 (2004) 16]. Transient transfection of IkappaBalpha mutant (IkappaBalphaM) cDNA into the mouse uterine cavity using hemagglutinating virus of Japan envelope vector suppressed uterine NF-kappaB activity less than half of that observed in control on days 3.5 and 4.5 p.c. IkappaBalphaM cDNA...

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Alteration of the timing of implantation by in vivo gene transfer: delay of implantation by suppression of nuclear factor kappaB activity and partial rescue by leukemia inhibitory factor.

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